Interviewer: "Speaking about drugs, you have spoken out against them..." 

Zappa: "Yeah." 

Interviewer: "That's... that's sort of... not the norm for a musician." 

Zappa: "That's another reason why I don't get my music on the radio because I'm totally out of step with reality.  No I'm not a religious fanatic.  I don't use drugs...  And I'm neither a republican nor a democrat, and uh... I'm reasonably sane." 

From interview with
Frank Zappa 1984
(video)